GO ID GO term # of direct and indirect annotations # of expert votes (out of 6) GO:0043037 translation 417 4 GO:0007010 cytoskeleton organization and biogenesis 286 4 GO:0006366 transcription from RNA polymerase II promoter 270 5 GO:0016192 vesicle-mediated transport 269 4 GO:0006082 organic acid metabolism 269 4 GO:0000279 M phase 256 6 GO:0016072 rRNA metabolism 249 4 GO:0045184 establishment of protein localization 244 4 GO:0007001 chromosome organization and biogenesis (sensu Eukaryota) 236 4 GO:0000278 mitotic cell cycle 222 4 GO:0005975 carbohydrate metabolism 219 6 GO:0006629 lipid metabolism 216 4 GO:0009308 amine metabolism 216 4 GO:0007046 ribosome biogenesis 211 4 GO:0006323 DNA packaging 201 6 GO:0006519 amino acid and derivative metabolism 195 5 GO:0006793 phosphorus metabolism 187 5 GO:0006310 DNA recombination 186 6 GO:0016071 mRNA metabolism 183 4 GO:0006974 response to DNA damage stimulus 168 5 GO:0006066 alcohol metabolism 157 5 GO:0006508 proteolysis and peptidolysis 154 5 GO:0006461 protein complex assembly 150 4 GO:0051186 cofactor metabolism 145 4 GO:0000902 cellular morphogenesis 142 4 GO:0007047 cell wall organization and biogenesis 141 4 GO:0000074 regulation of cell cycle 135 5 GO:0051321 meiotic cell cycle 129 5 GO:0008380 RNA splicing 126 4 GO:0016481 negative regulation of transcription 125 4 GO:0051301 cell division 124 4 GO:0006811 ion transport 106 4 GO:0006913 nucleocytoplasmic transport 105 5 GO:0006260 DNA replication 103 5 GO:0019953 sexual reproduction 100 4 GO:0000746 conjugation 100 5 GO:0030435 sporulation 99 4 GO:0051169 nuclear transport 99 5 GO:0007059 chromosome segregation 99 4 GO:0006399 tRNA metabolism 96 5 GO:0050801 ion homeostasis 96 4 GO:0007005 mitochondrion organization and biogenesis 90 5 GO:0009117 nucleotide metabolism 88 4 GO:0045333 cellular respiration 87 5 GO:0040029 "regulation of gene expression, epigenetic" 81 4 GO:0051325 interphase 79 5 GO:0015931 "nucleobase, nucleoside, nucleotide and nucleic acid transport" 78 4 GO:0019954 asexual reproduction 78 4 GO:0016458 gene silencing 76 5 GO:0006766 vitamin metabolism 72 5 GO:0030447 filamentous growth 72 4 GO:0051236 establishment of RNA localization 70 5 GO:0046483 heterocycle metabolism 69 4 GO:0009100 glycoprotein metabolism 69 5 GO:0006512 ubiquitin cycle 67 6 GO:0019236 response to pheromone 67 5 GO:0045941 positive regulation of transcription 65 4 GO:0006457 protein folding 62 6 GO:0006997 nuclear organization and biogenesis 62 5 GO:0006401 RNA catabolism 59 4 GO:0006970 response to osmotic stress 57 6 GO:0006352 transcription initiation 56 6 GO:0007264 small GTPase mediated signal transduction 56 5 GO:0006944 membrane fusion 55 5 GO:0006725 aromatic compound metabolism 55 6 GO:0006790 sulfur metabolism 53 6 GO:0006800 oxygen and reactive oxygen species metabolism 52 6 GO:0015849 organic acid transport 51 4 GO:0015837 amine transport 48 5 GO:0007034 vacuolar transport 46 5 GO:0008219 cell death 46 4 GO:0000067 DNA replication and chromosome cycle 42 5 GO:0007568 aging 41 4 GO:0007166 cell surface receptor linked signal transduction 39 4 GO:0006383 transcription from RNA polymerase III promoter 38 6 GO:0007033 vacuole organization and biogenesis 37 4 GO:0006473 protein amino acid acetylation 37 5 GO:0007031 peroxisome organization and biogenesis 36 5 GO:0006807 nitrogen compound metabolism 36 6 GO:0048308 organelle inheritance 35 4 GO:0042157 lipoprotein metabolism 35 5 GO:0007032 endosome organization and biogenesis 35 4 GO:0008643 carbohydrate transport 34 5 GO:0016485 protein processing 32 5 GO:0006914 autophagy 32 5 GO:0006112 energy reserve metabolism 31 6 GO:0006118 electron transport 31 6 GO:0006417 regulation of protein biosynthesis 30 4 GO:0006360 transcription from RNA polymerase I promoter 28 6 GO:0045185 maintenance of protein localization 27 5 GO:0043284 biopolymer biosynthesis 25 4 GO:0006818 hydrogen transport 24 6 GO:0006354 RNA elongation 23 6 GO:0007530 sex determination 22 4 GO:0031123 RNA 3'-end processing 20 4 GO:0009266 response to temperature 20 5 GO:0010035 response to inorganic substance 20 4 GO:0050790 regulation of enzyme activity 20 5 GO:0051052 regulation of DNA metabolism 20 5 GO:0007243 protein kinase cascade 20 5 GO:0008213 protein amino acid alkylation 20 5 GO:0006869 lipid transport 20 6 GO:0007155 cell adhesion 18 4 GO:0006081 aldehyde metabolism 18 6 GO:0019748 secondary metabolism 17 4 GO:0018193 peptidyl-amino acid modification 17 5 GO:0048284 organelle fusion 17 5 GO:0006113 fermentation 16 6 GO:0006353 transcription termination 15 6 GO:0019932 second-messenger-mediated signaling 15 5 GO:0043094 metabolic compound salvage 15 5 GO:0030705 cytoskeleton-dependent intracellular transport 15 5 GO:0009116 nucleoside metabolism 14 5 GO:0042594 response to starvation 13 4 GO:0006476 protein amino acid deacetylation 13 6 GO:0031023 microtubule organizing center organization and biogenesis 13 4 GO:0015893 drug transport 13 4 GO:0000160 two-component signal transduction system (phosphorelay) 12 6 GO:0006986 response to unfolded protein 12 6 GO:0006730 one-carbon compound metabolism 12 6 GO:0006056 mannoprotein metabolism 12 6 GO:0001510 RNA methylation 11 6 GO:0006839 mitochondrial transport 11 6 GO:0006308 DNA catabolism 11 6 GO:0030261 chromosome condensation 11 6 GO:0009415 response to water 10 5 GO:0008298 intracellular mRNA localization 10 5 GO:0045454 cell redox homeostasis 10 5 GO:0016050 vesicle organization and biogenesis 9 5 GO:0015891 siderophore transport 9 5 GO:0009306 protein secretion 9 4 GO:0006276 plasmid maintenance 9 6 GO:0051248 negative regulation of protein metabolism 9 5 GO:0007039 vacuolar protein catabolism 8 5 GO:0016074 snoRNA metabolism 8 5 GO:0051261 protein depolymerization 8 4 GO:0006518 peptide metabolism 8 5 GO:0051049 regulation of transport 7 5 GO:0006280 mutagenesis 7 6 GO:0051180 vitamin transport 6 6 GO:0009410 response to xenobiotic stimulus 6 5 GO:0007584 response to nutrients 6 4 GO:0009743 response to carbohydrate stimulus 6 4 GO:0016925 protein sumoylation 6 5 GO:0000338 protein deneddylation 6 6 GO:0015791 polyol transport 6 5 GO:0001522 pseudouridine synthesis 5 6 GO:0009225 nucleotide-sugar metabolism 5 5 GO:0051129 negative regulation of cell organization and biogenesis 5 4 GO:0007029 ER organization and biogenesis 5 5 GO:0006265 DNA topological change 5 6 GO:0016073 snRNA metabolism 4 5 GO:0009452 RNA capping 4 5 GO:0042176 regulation of protein catabolism 4 6 GO:0018065 protein-cofactor linkage 4 5 GO:0045116 protein neddylation 4 5 GO:0015833 peptide transport 4 5 GO:0042180 ketone metabolism 4 5 GO:0006984 ER-nuclear signaling pathway 4 6 GO:0051181 cofactor transport 4 5 GO:0006390 transcription from mitochondrial promoter 3 6 GO:0009268 response to pH 3 5 GO:0017006 protein-tetrapyrrole linkage 3 5 GO:0007009 plasma membrane organization and biogenesis 3 4 GO:0050874 organismal physiological process 3 5 GO:0048285 organelle fission 3 5 GO:0042044 fluid transport 3 5 GO:0009581 detection of external stimulus 3 4 GO:0016032 viral life cycle 2 4 GO:0009847 spore germination 2 5 GO:0051238 sequestering of metal ion 2 5 GO:0009303 rRNA transcription 2 5 GO:0009966 regulation of signal transduction 2 4 GO:0051252 regulation of RNA metabolism 2 6 GO:0016926 protein desumoylation 2 5 GO:0018987 osmoregulation 2 5 GO:0000280 nuclear division 2 4 GO:0006662 glycerol ether metabolism 2 6 GO:0015976 carbon utilization 2 4 GO:0007624 ultradian rhythm 1 5 GO:0042214 terpene metabolism 1 5 GO:0009302 snoRNA transcription 1 5 GO:0009636 response to toxin 1 4 GO:0009314 response to radiation 1 5 GO:0045471 response to ethanol 1 5 GO:0046677 response to antibiotic 1 5 GO:0001101 response to acid 1 5 GO:0045595 regulation of cell differentiation 1 4 GO:0050821 protein stabilization 1 5 GO:0051258 protein polymerization 1 4 GO:0009305 protein amino acid biotinylation 1 5 GO:0018410 peptide or protein carboxyl-terminal blocking 1 5 GO:0030397 membrane disassembly 1 5 GO:0044419 interaction between organisms 1 4 GO:0007030 Golgi organization and biogenesis 1 5 GO:0006858 extracellular transport 1 6 GO:0006266 DNA ligation 1 6 GO:0006033 chitin localization 1 6 GO:0016998 cell wall catabolism 1 5 GO:0046713 boron transport 1 4